Table 1.
Controlled studies on steroid therapy of neurocysticercosis.
Study (year) | Details | Entry criteria | Intervention | Imaging results (resolution) | Seizures | Ref. |
---|---|---|---|---|---|---|
Mall et al. (2003) | Randomized, not blinded. All ages | Seizure <10 days and SEL | 1 mg/kg prednisolone × 10 days with 4-day taper | Significantly improved in steroid group (88 vs 52%) at 6 months | Significantly fewer in steroid group (2 vs 13%) at 6 months | [45] |
Garg et al. (2006) | Randomized, blinded. All ages. | Seizure <14 days and SEL | 1 mg/kg prednisolone × 10 days with 4-day taper | No difference at 6 months | Significantly fewer in steroid group (12 vs 48%) at 9 months | [46] |
Prakash et al. (2006) | Randomized. All ages | Seizure <14 days and SEL | 1 g/1.72 m2 iv. methyl prednisolone × 5 days | Significantly improved in steroid group (60 vs 18.5%) at 2 months | No significant decrease in seizures in steroid group (16 vs 33%) | [48] |
Kishore et al. (2007) | Randomized. All ages | Seizure <7 days and SEL | 1 mg/kg prednisolone × 7 days + 3-day taper | Significantly improved in steroid group (68 vs 53%) at 8–12 weeks | Significantly fewer seizures in steroid group (10.6 vs 26.7%) | [47] |
iv.: Intravenous; SEL: Single enhancing granulomatous lesion.