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. Author manuscript; available in PMC: 2013 Jul 24.
Published in final edited form as: J Am Chem Soc. 2013 Feb 25;135(9):3613–3619. doi: 10.1021/ja312314b

Figure 1.

Figure 1

(a) Intermolecular ion pairs involving Lys side-chain NH3+ groups (cyan spheres) and DNA phosphate or phosphorodithioate groups (yellow/red spheres) studied in this work. Two 24-bp DNA duplexes with the same sequence (the recognition site in bold) were used: Duplex I with no chemical modification; and Duplex II with a phosphorodithioate incorporated at the position of the ion pair with Lys57. (b) Overlaid HISQC spectra of the Lys NH3+ groups recorded for HoxD9 homeodomain complexes with Duplex I (blue) and with Duplex II (red) at 35 °C.