Table 1.
Well-characterized T cell-defined wt p53 peptides available for vaccine use
| HLA class I-restricted CD8+ T cell-defined peptides | ||
|---|---|---|
| wt p53 peptide | sequences | reference |
| HLA-A2 restricted | ||
| 65-73 | RMPEAAPPV | [58] |
| 149-157 | STPPPGTRV | [10, 40] |
| 187-197 | GLAPPQHLIRV | [55] |
| 217-225 | VVPYEPPEV | [59] |
| 264-272 | LLGRNSFEV | [10, 12, 40] |
| HLA-A24-restricted | ||
| 125–134 | TYPALNKMF | [22] |
| 161–169 | AIYKQSQHM | [60] |
| 204–212 | EYLDDRNTF | [22] |
|
| ||
| HLA class II-restricted CD4+ T cell-defined peptides | ||
| HLA-DR1/4 | ||
| 108-122 | GFRLGFLHSGTASV | [60] |
| 110-124 | RLGFLHSGTASVTC | [20] |
| HLA-DR7/11 | ||
| 25-35 | LWKLLPENNVLSP | [21] |
| HLA-DP5 | ||
| 108-122 | GFRLGFLHSGTAKSV | [44] |
| 153-166 | PGTRVRAMAIYKQS | [44] |