Table 4.
Predicted upstream regulators in KC epithelium and stroma.
| Epithelium | Stroma | ||||
|---|---|---|---|---|---|
| Regulator | Activation Z-Score | P - value | Regulator | Activation Z-Score | P - value |
| SMAD7 | 2.020 | 4.09E-06 | MYCN | 4.061 | 2.30E-18 |
| NFE2L2 | −4.233 | 1.82E-09 | SMAD7 | 2.555 | 1.38E-04 |
| TP53 | −3.119 | 2.90E-12 | SPDEF | 2.121 | 6.25E-05 |
| VEGFA | −2.961 | 8.12E-04 | WISP2 | 2.000 | 5.67E-03 |
| NFkB | −2.782 | 1.91E-02 | FGF2 | −3.531 | 2.56E-05 |
| FGF2 | −2.511 | 3.53E-04 | CEBPB | −3.364 | 1.67E-06 |
| XBP1 | −2.470 | 5.03E-05 | HNF1A | −3.201 | 1.15E-09 |
| INSR | −2.429 | 6.01E-04 | CHUK | −3.116 | 7.26E-03 |
| MAPK14 | −2.279 | 1.09E-03 | IKBKB | −2.717 | 4.68E-03 |
| EPAS1 | −2.194 | 1.63E-02 | MTPN | −2.630 | 1.53E-03 |
| LEP | −2.129 | 1.67E-03 | P38 MAPK | −2.520 | 5.89E-03 |
| SP1 | −2.093 | 1.84E-04 | TGFβ1 | −2.314 | 9.72E-17 |
| TGFβ1 | −2.086 | 2.83E-12 | CREBBP | −2.158 | 4.09E-02 |
| PPARGC1A | −2.021 | 9.99E-04 | TGFβ2 | −2.138 | 7.38E-03 |