Table 3. Median protein expression levels of reverse phase protein arrays (RPPAs) in tumours with HSP/GRP-patterns A and B identified by unsupervised hierarchical cluster analysis.
| Protein | HSP/GRP-pattern A | HSP/GRP-pattern B | P-value | ||
|---|---|---|---|---|---|
|
Median protein expression level (min–max) | |||||
| HSP60 |
560 (188–1508) |
↑ |
290 (87–749) |
↓ |
<0.001 |
| HSP70 |
331 (109–597) |
↑ |
283 (143–671) |
↓ |
0.069 |
| HSP90 |
148 (77–286) |
↓ |
184 (75–361) |
↑ |
0.003 |
| GRP78 |
621 (149–1444) |
↑ |
402 (123–941) |
↓ |
<0.001 |
| GRP94 |
429 (115–899) |
↑ |
253 (95–810) |
↓ |
<0.001 |
| HSP27 |
122 (56–255) |
↓ |
223 (65–463) |
↑ |
<0.001 |
| p-HSP27 (Ser15) |
142 (52–357) |
↓ |
312 (109–766) |
↑ |
<0.001 |
| p-HSP27 (Ser78) |
216 (106–566) |
↓ |
392 (172–1275) |
↑ |
<0.001 |
| p-HSP27 (Ser82) | 82 (33–239) | ↓ | 190 (52–477) | ↑ | <0.001 |
Abbreviations: GRP=glucose-related protein; HSP=heat-shock protein.