Table 3. Gene ontology of genes differentially expressed in (a) group 1 and (b) group 2, both relative to group 3.
| Cluster | GO Term | Fold enrichment | P-value |
|---|---|---|---|
|
(a) | |||
| Annotation cluster 1 | Enrichment score: 34.87 | ||
| GOTERM_BP_FAT | GO:0000279∼M phase | 8.99 | 0.0000 |
| GOTERM_BP_FAT | GO:0022403∼cell cycle phase | 7.49 | 0.0000 |
| GOTERM_BP_FAT | GO:0007067∼mitosis | 10.46 | 0.0000 |
| GOTERM_BP_FAT | GO:0000280∼nuclear division | 10.46 | 0.0000 |
| GOTERM_BP_FAT | GO:0000087∼M phase of mitotic cell cycle | 10.28 | 0.0000 |
| GOTERM_BP_FAT | GO:0048285∼organelle fission | 10.05 | 0.0000 |
| GOTERM_BP_FAT | GO:0022402∼cell cycle process | 5.82 | 0.0000 |
| GOTERM_BP_FAT |
GO:0000278∼mitotic cell cycle |
7.11 |
0.0000 |
| Annotation cluster 2 | Enrichment score: 29.41 | ||
| GOTERM_MF_FAT | GO:0004984∼olfactory receptor activity | 9.12 | 0.0000 |
| GOTERM_BP_FAT | GO:0007608∼sensory perception of smell | 7.74 | 0.0000 |
| GOTERM_BP_FAT | GO:0007606∼sensory perception of chemical stimulus | 7.17 | 0.0000 |
| KEGG_PATHWAY | hsa04740:Olfactory transduction | 5.66 | 0.0000 |
| GOTERM_BP_FAT | GO:0007600∼sensory perception | 4.29 | 0.0000 |
| GOTERM_BP_FAT | GO:0050890∼cognition | 3.82 | 0.0000 |
| GOTERM_BP_FAT | GO:0007186∼G-protein-coupled receptor protein signalling pathway | 3.39 | 0.0000 |
| GOTERM_BP_FAT | GO:0050877∼neurological system process | 2.99 | 0.0000 |
| GOTERM_BP_FAT |
GO:0007166∼cell surface receptor linked signal transduction |
2.15 |
0.0000 |
| Annotation cluster 3 | Enrichment score: 10.49 | ||
| GOTERM_BP_FAT | GO:0065004∼protein-DNA complex assembly | 11.36 | 0.0000 |
| GOTERM_BP_FAT | GO:0031497∼chromatin assembly | 10.80 | 0.0000 |
| GOTERM_BP_FAT | GO:0006334∼nucleosome assembly | 10.62 | 0.0000 |
| GOTERM_BP_FAT | GO:0034728∼nucleosome organisation | 9.60 | 0.0000 |
| GOTERM_BP_FAT | GO:0006333∼chromatin assembly or disassembly | 7.40 | 0.0000 |
| GOTERM_BP_FAT | GO:0034621∼cellular macromolecular complex subunit organisation | 3.55 | 0.0000 |
| GOTERM_BP_FAT | GO:0034622∼cellular macromolecular complex assembly | 3.69 | 0.0000 |
| GOTERM_BP_FAT |
GO:0006325∼chromatin organisation |
2.73 |
0.0001 |
| Annotation cluster 4 | Enrichment score: 8.65 | ||
| GOTERM_BP_FAT | GO:0051327∼M phase of meiotic cell cycle | 7.67 | 0.0000 |
| GOTERM_BP_FAT | GO:0007126∼meiosis | 7.67 | 0.0000 |
| GOTERM_BP_FAT |
GO:0051321∼meiotic cell cycle |
7.52 |
0.0000 |
| Annotation CLUSTER 5 | Enrichment score: 8.27 | ||
| GOTERM_BP_FAT | GO:0006974∼response to DNA damage stimulus | 3.90 | 0.0000 |
| GOTERM_BP_FAT | GO:0006281∼DNA repair | 4.47 | 0.0000 |
| GOTERM_BP_FAT | GO:0033554∼cellular response to stress | 2.66 | 0.0000 |
|
(b) | |||
| Annotation cluster 1 | Enrichment score: 66.78 | ||
| GOTERM_BP_FAT | GO:0022403∼cell cycle phase | 10.48 | 0.0000 |
| GOTERM_BP_FAT | GO:0000279∼M phase | 11.91 | 0.0000 |
| GOTERM_BP_FAT |
GO:0022402∼cell cycle process |
8.34 |
0.0000 |
| Annotation cluster 2 | Enrichment score: 53.36 | ||
| GOTERM_BP_FAT | GO:0000278∼mitotic cell cycle | 9.83 | 0.0000 |
| GOTERM_BP_FAT | GO:0007067∼mitosis | 13.57 | 0.0000 |
| GOTERM_BP_FAT | GO:0000280∼nuclear division | 13.57 | 0.0000 |
| GOTERM_BP_FAT | GO:0000087∼M phase of mitotic cell cycle | 13.33 | 0.0000 |
| GOTERM_BP_FAT |
GO:0048285∼organelle fission |
13.04 |
0.0000 |
| Annotation cluster 3 | Enrichment score: 21.83 | ||
| GOTERM_BP_FAT | GO:0006281∼DNA repair | 7.23 | 0.0000 |
| GOTERM_BP_FAT | GO:0006974∼response to DNA damage stimulus | 6.13 | 0.0000 |
| GOTERM_BP_FAT |
GO:0033554∼cellular response to stress |
4.29 |
0.0000 |
| Annotation cluster 4 | Enrichment score: 14.86 | ||
| GOTERM_BP_FAT | GO:0007126∼meiosis | 10.47 | 0.0000 |
| GOTERM_BP_FAT | GO:0051327∼M phase of meiotic cell cycle | 10.47 | 0.0000 |
| GOTERM_BP_FAT |
GO:0051321∼meiotic cell cycle |
10.26 |
0.0000 |
| Annotation cluster 5 | Enrichment score: 13.93 | ||
| GOTERM_BP_FAT | GO:0065004∼protein-DNA complex assembly | 12.82 | 0.0000 |
| GOTERM_BP_FAT | GO:0031497∼chromatin assembly | 12.33 | 0.0000 |
| GOTERM_BP_FAT | GO:0034728∼nucleosome organisation | 11.04 | 0.0000 |
| GOTERM_BP_FAT | GO:0006334∼nucleosome assembly | 11.66 | 0.0000 |
| GOTERM_BP_FAT | GO:0006333∼chromatin assembly or disassembly | 8.45 | 0.0000 |
| GOTERM_BP_FAT | GO:0034622∼cellular macromolecular complex assembly | 4.40 | 0.0000 |
| GOTERM_BP_FAT | GO:0006325∼chromatin organisation | 3.21 | 0.0000 |
Abbreviation: GO=gene ontology.
Genes with at least two-fold (q⩽0.05) differential expression in group 1 or group 2 vs group 3 were analysed using DAVID (http://david.abcc.ncifcrf.gov). The top five most highly enriched clusters of GO terms are presented.