Table 1. Comparison of clinicopathologic features between Ron+ and Ron− HNSCCs.
| Ron+ HNSCCs, n=83 (65.4%) | Ron− HNSCCs, n=44 (34.6%) | P-value | |
|---|---|---|---|
| Age (years) |
61.1±11.8 |
55.7±9.4 |
<0.01 |
|
Sex | |||
| Female | 18 (21.7%) | 10 (22.7%) | |
| Male |
65 (78.3%) |
34 (77.3%) |
NS |
|
Tumour sites | |||
| Oropharynx | 68 (81.9%) | 29 (65.9%) | |
| Larynx |
15 (18.1%) |
15 (34.1%) |
0.05 |
| Smoking (pack years) |
37.8±36.2 |
36.2±29.7 |
NS |
|
Differentiation | |||
| Missing | 2 (2.4%) | 0 | |
| Well | 12 (14.5%) | 6 (13.6%) | |
| Moderate | 46 (55.4%) | 31 (70.5%) | |
| Poor |
23 (27.7%) |
7 (15.9%) |
NS |
|
Perineural invasion | |||
| Missing | 22 (26.5%) | 14 (31.8%) | |
| Yes | 35 (42.2%) | 18 (40.9%) | |
| No |
26 (31.3%) |
12 (27.3%) |
NS |
|
Lymphovascular invasion | |||
| Missing | 15 (18.1%) | 2 (4.5%) | |
| Yes | 23 (27.7%) | 19 (43.2%) | |
| No |
45 (54.2%) |
23 (52.3%) |
NS |
| Tumour size (log cm3) |
3.23±1.25 |
2.97±1.35 |
NS |
|
T stage | |||
| Tx | 1 (1.2%) | 1 (2.3%) | |
| Tis/T1/T2 | 23 (27.7%) | 15 (34.1%) | |
| T3 /T4 |
59 (71.1%) |
28 (63.6%) |
NS |
|
N stage | |||
| Nx | 11 (13.2%) | 5 (11.4%) | |
| N0/N1 | 40 (48.2%) | 22 (50%) | |
| N2/N3 |
32 (38.6%) |
17 (38.6%) |
NS |
|
Overall stage | |||
| Missing | 9 (10.8%) | 5 (11.4%) | |
| 1–2 | 9 (10.8%) | 5 (11.4%) | |
| 3–4 |
65 (78.4%) |
34 (77.2%) |
NS |
| Recurrence | 7 (8.4%) | 4 (9.1%) | |
Abbreviations: HNSCC=head and neck squamous cell carcinoma; NS=not significant.