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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Nat Immunol. 2013 Jun 23;14(8):804–811. doi: 10.1038/ni.2637

Figure 4. IL-20R cytokines suppress pro-IL-1β transcription.

Figure 4

(a) mRNA expression in infected tissue compared to uninfected control at indicated time points after MRSA infection of wild type mice. (b) mRNA expression in infected tissue two hours after infection of wild type (WT), Il20rb−/−, or recombinant cytokine-treated wild type mice normalized to WT response. (c) mRNA expression in infected tissue from WT, Il20rb−/−, or cytokine-treated mice six days after infection normalized to WT response. (d-f) Lesion size (d), day six bacterial burden (e), and pro-IL-1β transcript levels (f) in Stat3WT/ΔV463 mice with and without rmIL-19. Data shown are representative of 2-5 independent experiments, each using at least 5 mice per group, and displayed as mean + s.e.m.