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Through-and-through 2 mm holes are punched in the middle of the ear pinnae, clearly seen at day 0 in both C57BL/6J (a) and MRL/MpJ (b). By day 30, however, earholes remain clearly seen in C57BL/6J (c) but have been replaced by native tissue in MRL/MpJ (d), denoting regeneration (Adapted from Clark et al. 1998).
