Table 2.

Multivariate Cox proportion hazard model for relapse, clonal evolution and survival

	Relapse			Clonal Evolution			Survival
Risk factor	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Telomere length	0.16	0.03, 0.69	0.01	0.29	0.11, 0.76	0.01	0.35	0.17, 0.73	0.005
Age (years)	1.03	1.01, 1.05	0.005	1.03	1.00, 1.05	0.01	1.03	1.02, 1.05	<0.001
ARC (/μL)	0.99	0.63, 1.55	0.96	1.10	0.55, 2.19	0.79	0.63	0.41, 0.97	0.03
ALC (/μL)	1.31	0.55, 3.10	0.54	1.16	0.51, 2.66	0.72	0.89	0.48, 1.66	0.72
ANC (/μL)	1.20	0.67, 2.16	0.54	0.70	0.38, 1.27	0.24	0.95	0.65, 1.38	0.78
Platelet (/μL)	0.80	0.46, 1.38	0.42	0.76	0.45, 1.28	0.30	1.11	0.73, 1.67	0.63

Continuous telomere length was used for relapse due to the linear relationship between relapse and telomere length. For clonal evolution and survival, short telomere was defined as an age-adjusted telomere length < first quartile and long telomere as an age-adjusted telomere length > first quartile. Natural log-transformed ARC, ALC, ANC and platelet count were used to reduce the skewness of these variables. ARC, absolute reticulocyte count, ALC, absolute lymphocyte count, ANC, absolute neutrophil count; HR; hazard ratio; 95% CI, 95% Confidence Interval.