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. Author manuscript; available in PMC: 2013 Jul 24.
Published in final edited form as: Am J Hypertens. 2012 Apr 26;25(7):812–817. doi: 10.1038/ajh.2012.43

Table III.

Comparison of Phenotypes of LSD1 Gene Variants in Humans and LSD1+/−Mice

Human studies Animal studies
Polymorphic Variants of LSD1 in African Americans:

  • Hypertension

  • Salt sensitivity of blood pressure

  • Decreased serum aldosterone on HS diet

  • Suppressed PRA on HS diet

  • Normal renin status on LS diet

  • Potentially abnormal renal vascular response to HS diet

 Heterozygous LSD1 Knockout Mice:

  • Hypertension

  • Salt sensitivity of blood pressure

  • Decreased serum and 24-hour urinary aldosterone on HS diet

  • Suppressed PRA on HS diet

  • Suppressed eNAC on HS diet

  • Vascular enhanced contraction/reduced relaxation on HS diet

HS=liberal sodium; LS=low sodium; PRA=plasma renin activity