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. 2013 Jul 24;33(30):12154–12170. doi: 10.1523/JNEUROSCI.3263-12.2013

Figure 3.

Figure 3.

Convergence to a common intrinsic computation parallels development of voltage-gated currents. A, Population STAs for immature and mature neurons. B, R̂σ[ŝ] for single σ conditions for immature (n = 15, blue) and mature (n = 26, red) groups. C, Distribution of pairwise DN for immature and mature neurons shown in A and B. Input–output relation shape is more consistent for mature (〈DN〉 = 0.15 ± 0.01 bits, n = 325) than for immature (〈DN〉 = 0.84 ± 0.08 bits, n = 120) neurons. D, Voltage-clamp protocol to measure maximal in vitro currents, INa and IK, in immature (top) and mature (bottom) neurons. Steps start at a holding potential of −70 mV and range from −90 to 40 mV. E, INa versus IK measured as in E. Warmer colors indicate increasing age (E14–P11, n = 169).