Figure 4.
Fascin is upregulated in migrating neuroblasts. A, Immunostaining of sagittal brain sections shows strong fascin expression along the RMS in both P7 and adult mice. B, C, Confocal images from P7 mouse SVZ sections showing that fascin immunostaining virtually overlaps with Dcx+ migrating neuroblasts (B), but is excluded from GFAP+ stem cells and astrocytes (C). D, Hardly any colocalization is observed with Mash1+ transit-amplifying progenitors. Scale bars: A, 500 μm; B–D, 10 μm.