Table 1. Characteristics Of Participants: HIV Uninfected, HIV Infected, And HIV Infected With A Nadir CD4 Cell Count < 200 Cells/mm3 .
| HIV uninfected (n = 300) | p-value† HIV uninfected/infected | HIV infected (n = 300) | p-value† HIV uninfected/nadir CD4 cell count | Nadir CD4 cell count (n = 18) | p-value‡ trend | |
| Age (years) | 44.0 ± 7.81 | 0.971 | 44.0 ± 8.04 | 0.679 | 44.8 ± 8.48 | 0.904 |
| Men/women (n) | 116/184 | 1.000 | 116/184 | 0.135 | 10/8 | 0.316 |
| Body mass index (kg/m2) | 22.8 ± 5.48 | 0.916 | 22.9 ± 5.59 | 0.122 | 20.8 ± 3.96 | 0.258 |
| Systolic blood pressure (mmHg) | 129 ± 21.8 | 0.003 | 124 ± 21.8 | 0.309 | 124 ± 17.5 | 0.015 |
| Diastolic blood pressure (mmHg) | 85.9 ± 14.3 | 0.099 | 84.0 ± 14.7 | 0.145 | 80.9 ± 10.6 | 0.191 |
| Mean arterial pressure (mmHg) | 100 ± 16.1 | 0.024 | 97.5 ± 16.7 | 0.179 | 95.3 ± 12.1 | 0.179 |
| Carotid radialis pulse wave velocity (m/s) | 10.9 ± 2.30 | 0.606 | 11.1 ± 2.10 | 0.307 | 11.5 ± 2.30 | 0.561 |
| Lipids: | ||||||
| HDL-C (mmol/l) | 1.70 ± 0.71 | < 0.001 | 1.23 ± 0.58 | < 0.001 | 1.07 ± 0.47 | < 0.001 |
| TG (mmol/l) | 1.15 ± 0.75 | 0.031 | 1.29 ± 0.77 | 0.814 | 1.19 ± 0.76 | 0.085 |
| TG:HDL-C ratio | 0.86 ± 1.21 | < 0.001 | 1.41 ± 1.47 | 0.006 | 1.19 ± 0.21 | < 0.001 |
| Inflammatory markers: | ||||||
| hsIL-6 (pg/ml) | 3.72 (1.11–16.9) | < 0.001 | 4.70 (1.29–20.9) | 0.124 | 5.03 (1.10–22.3) | 0.002 |
| hsCRP (mg/l) | 2.13 (0.23–29.2) | < 0.001 | 3.31 (0.32–50.4) | 0.012 | 5.34 (0.56–62.1) | 0.001 |
| sICAM-1 (ng/ml) | 405 (111–1345) | < 0.001 | 577 (192–1610) | 0.009 | 696 (194–1884) | < 0.001 |
| sVCAM-1 (ng/ml) | 397 (19–2252) | < 0.001 | 847 (101–3230) | 0.001 | 1262 (143–3421) | < 0.001 |
| Coagulation markers: | ||||||
| Fibrinogen (g/l) | 2.99 (1.39–7.19) | 0.041 | 2.75 (1.29–6.99) | 0.785 | 3.11 (1.39–9.00) | 0.073 |
| PAI-1 (IU/ml) | 1.39 (0.01–17.3) | 0.681 | 1.52 (0.01–18.8) | 0.433 | 0.83 (0.01–17.4) | 0.563 |
| Glucose (mmol/l) | 5.50 ± 1.10 | 0.126 | 5.35 ± 1.26 | 0.052 | 4.97 ± 0.29 | 0.122 |
| eCrCl (ml/min) | 79.7 (16.1–157) | 0.150 | 73.5 (15.1–160) | 0.790 | 76.5 (9.58–163) | 0.345 |
| Tobacco users, n (%) | 137 (45.6) | 0.410 | 127 (42.3) | 0.082 | 12 (66.7) | 0.071 |
| Alcohol users, n (%) | 103 (34.3) | 0.543 | 96 (32.0) | 0.693 | 7 (38.9) | 0.678 |
n: number of participants; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; hsIL-6: high-sensitivity interleukin 6; hsCRP: highsensitivity C-reactive protein; sICAM-1: serum intercellular adhesion molecule-1; sVCAM-1: serum vascular cell adhesion molecule-1; PAI-1: plasminogen activator inhibitor-1.
Data are expressed as arithmetic mean ± standard deviation, geometric mean (5th and 95th percentile intervals) or % of n.
†p-values between uninfected/infected and uninfected/nadir CD4 cell count were obtained with independent t-test.
‡p-values trend was obtained with ANOVA, and for gender, tobacco and alcohol users, Chi-square test was used.