Table 5.
Estimates of D9D activity according to genotype for each SCD1 SNP in Caucasians
|
[18:2c9t11/18:1 t11] in males |
[18:2c9t11/18:1 t11] in females |
||||||
---|---|---|---|---|---|---|---|---|
MM | Mm | mm | P-value | MM | Mm | mm | P-value | |
rs10883463 |
1.077 ± 0.036a |
0.769 ± 0.048b |
- |
<0.01* |
1.206 ± 0.036 |
1.244 ± 0.061 |
1.505 ± 0.170 |
0.75 |
rs17669878 |
1.079 ± 0.070 |
0.977 ± 0.040 |
1.064 ± 0.076 |
0.23 |
1.248 ± 0.041 |
1.195 ± 0.050 |
1.207 ± 0.074 |
0.72 |
rs2060792 |
1.015 ± 0.037 |
0.998 ± 0.061 |
1.215 ± 0.179 |
0.62 |
1.251 ± 0.053 |
1.175 ± 0.036 |
1.229 ± 0.088 |
0.58 |
rs3071 |
1.037 ± 0.052 |
1.024 ± 0.046 |
0.913 ± 0.051 |
0.78 |
1.202 ± 0.031 |
1.224 ± 0.059 |
1.238 ± 0.105 |
0.87 |
rs3793766 |
1.003 ± 0.036 |
1.083 ± 0.078 |
1.200 |
0.59 |
1.217 ± 0.035 |
1.209 ± 0.057 |
1.084 ± 0.391 |
0.94 |
rs3793767 |
0.939 ± 0.042 |
1.043 ± 0.051 |
1.111 ± 0.097 |
0.25 |
1.178 ± 0.043 |
1.252 ± 0.052 |
1.200 ± 0.054 |
0.81 |
rs490726 |
1.073 ± 0.042 |
0.960 ± 0.053 |
0.856 ± 0.344 |
0.23 |
1.215 ± 0.041 |
1.217 ± 0.046 |
1.229 ± 0.107 |
0.99 |
rs522951 |
1.044 ± 0.046 |
1.011 ± 0.050 |
1.019 ± 0.081 |
0.78 |
1.125 ± 0.055 |
1.252 ± 0.049 |
1.237 ± 0.048 |
0.42 |
rs569184 |
1.010 ± 0.036 |
1.060 ± 0.079 |
1.200 |
0.72 |
1.223 ± 0.035 |
1.198 ± 0.054 |
0.637 ± 0.055 |
0.38 |
rs575338 | 1.024 ± 0.042 | 1.024 ± 0.045 | 1.003 ± 0.155 | 0.99 | 1.193 ± 0.029 | 1.291 ± 0.098 | 1.188 ± 0.084 | 0.44 |
Results of analysis of 10 SNPs from SCD1 for associations with D9D activity index [182c9t11:181 t11]. Different letters (a or b) denote values that are significantly different between groups. P-values were determined using linear regression models which were adjusted for BMI, age, % of Total Energy from Dietary Fat and physical activity. Caucasian Males: n = 113; Caucasian females: n = 298; Asian Males: n = 98; Asian Females: n = 277. Abbreviations: D9D, delat-9-desaturase; M, major; m, minor; ‘-’ indicates that no subjects with this genotype were present in this population.