Table 2.
Correlation of DWI and MRP parameters with clinical outcome in HCC and tumor thrombus
| |
|
Baseline |
|
Percent changes (%) |
|
||
|---|---|---|---|---|---|---|---|
| Parameters |
SD or PR |
PD |
P value |
SD or PR |
PD |
P value | |
| (Median, Range) | (Median, Range) | (Median, Range) | (Median, Range) | ||||
|
RECIST |
|
|
|
|
|
|
|
|
HCC (cm) |
9.50, 2.30 ~ 17.00 |
10.30, 4.30 ~ 10.3 |
0.255 |
1.15, –43.48 ~ 8.46 |
33.98, 20.71 ~ 58.23 |
0.0002 |
|
|
Tumor thrombus(mm) |
26.42, 22.14 ~ 30.70 |
31.48, 24.65 ~ 38.34 |
0.110 |
−10.22, –25.62 ~ 10.26 |
7.72, –28.52 ~ 42.92 |
0.260 |
|
|
mRECIST |
|
|
|
|
|
|
|
|
HCC (cm) |
10.14, 2.15 ~ 19.56 |
6.12, 2.24 ~ 15.86 |
0.290 |
1.94, –19.80 ~ 15.86 |
0.49, –19.84 ~ 6.70 |
0.360 |
|
|
DWI |
|
|
|
|
|
|
|
|
HCC |
ADC (×10-3mm2/s) |
0.86, 0.58 ~ 0.99 |
0.93, 0.8 ~ 1.09 |
0.15 |
22.42, –8.99 ~ 51.72 |
22.22, –12.84 ~ 25.81 |
0.300 |
|
Tumor thrombus |
ADC (×10-3mm2/s) |
0.66, 0.60 ~ 0.73 |
0.96, 0.79 ~ 1.14 |
0.290 |
13.34, –13.28 ~ 39.94 |
20.32, –62.33 ~ 114.23 |
0.140 |
|
MRP |
|
|
|
|
|
|
|
|
HCC |
Ktrans (min−1) |
2.35, 0.90 ~ 4.81 |
1.29, 1.00 ~ 2.80 |
0.402 |
−54.98, –83.37 ~ –10.00 |
−17.83, –72.09 ~ –6.00 |
0.014 |
|
Kep (min−1) |
4.25, 1.00 ~ 41.75 |
1.54, 1.00 ~ 3.01 |
0.18 |
−54.73,– 96.32 ~ −5.04 |
−12.19, –70.17 ~ 28.04 |
0.048 |
|
|
EVF |
0.83, 0.34 ~ 1.00 |
0.95, 0.84 ~ 1.00 |
0.065 |
−2.38, –47.50 ~ 61.76 |
-6.45, –27.37 ~ –2.38 |
0.331 |
|
| Tumor thrombus |
Ktrans (min−1) |
1.96, 0.93 ~ 2.99 |
1.73, 1.05 ~ 2.41 |
0.350 |
−55.00, –72.65 ~ −47.35 |
−20.04, –63.23 ~ 24.14 |
0.006 |
|
Kep (min−1) |
2.54, 1.05 ~ 4.03 |
1.97, 1.18 ~ 2.76 |
0.230 |
−45.53, –67.42 ~ −23.64 |
−30.58, –80.01 ~ 18.98 |
0.090 |
|
| EVF | 0.81, 0.70 ~ 0.92 | 0.89, 0.82 ~ 0.98 | 0.110 | −15.70, –31.95 ~ 0.56 | −29.65, –38.12 ~ −21.07 | 0.060 | |
Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient; SD Partial disease; PR Partial response; PD Progressive disease.