Table 3.
Correlation of DWI and MRP parameters with PFS in HCC and tumor thrombus
| |
|
Baseline |
|
Percent changes (%) |
|
||
|---|---|---|---|---|---|---|---|
| Parameters |
PFS>6 months |
PFS6 ≤ months |
P value |
PFS>6 months |
PFS6 ≤ months |
P value | |
| (Median, Range) | (Median, Range) | (Median, Range) | (Median, Range) | ||||
|
RECIST |
|
|
|
|
|
|
|
|
HCC (cm) |
10.00, 5.20 ~ 14.00 |
10.00, 2.30 ~ 17.00 |
0.682 |
3.57, –36.54 ~ 35.00 |
7.60, –43.48 ~ 58.23 |
0.875 |
|
|
Tumor thrombus(mm) |
23.87, 22.14 ~ 28.50 |
30.79, 24.65 ~ 38.34 |
0.114 |
−15.23, –25.62 ~ 10.26 |
9.72, –28.52 ~ 42.92 |
0.019 |
|
|
mRECIST |
|
|
|
|
|
|
|
|
HCC (cm) |
10.70, 2.15 ~ 19.56 |
9.66, 2.24 ~ 15.86 |
0.207 |
−0.88, –11.16 ~ 11.00 |
1.89, –19.84 ~ 15.86 |
0.517 |
|
|
DWI |
|
|
|
|
|
|
|
|
HCC |
ADC (×10-3mm2/s) |
0.83, 0.65 ~ 1.01 |
0.90, 0.69 ~ 1.09 |
0.570 |
19.48, –12.84 ~ 40.00 |
22.22, –8.99 ~ 51.72 |
0.825 |
|
Tumor thrombus |
ADC (×10-3mm2/s) |
0.74, 0.60 ~ 1.03 |
0.93, 0.79 ~ 1.14 |
0.085 |
10.38, –13.28 ~ 39.94 |
21.11, –62.33 ~ 114.23 |
0.315 |
|
MRP |
|
|
|
|
|
|
|
|
HCC |
Ktrans (min−1) |
2.80, 1.00 ~ 4.81 |
1.70, 0.90 ~ 4.1 |
0.043 |
−52.27, –83.37 ~ −7.00 |
−41.25, –75.61 ~ -6.00 |
0.467 |
| |
Kep (min−1) |
3.01, 1.00 ~ 41.75 |
2.79, 1.27 ~ 4.36 |
0.100 |
−49.58, – 96.32 ~ 28.04 |
−46.33, –77.05 ~ -1.67 |
0.914 |
| |
EVF |
0.93, 0.57 ~ 1.00 |
0.88, 0.34 ~ 1.00 |
0.590 |
−8.77, –47.50 ~ 20.55 |
–2.38, –30.12 ~ 61.76 |
0.022 |
|
Tumor thrombus |
Ktrans (min−1) |
1.65, 0.93 ~ 2.33 |
1.98, 1.05 ~ 2.99 |
0.374 |
−58.48, –72.65 ~ −47.35 |
−23.11, –63.23 ~ 24.14 |
0.005 |
| |
Kep (min−1) |
2.43, 1.32 ~ 4.03 |
1.95, 1.05 ~ 2.76 |
0.220 |
−42.53, –67.42 ~ −23.64 |
−34.58, –80.01 ~ 18.98 |
0.135 |
| EVF | 0.78, 0.70 ~ 0.92 | 0.88, 0.82 ~ 0.98 | 0.120 | −11.30, –31.95 ~ 0.56 | −22.43, –38.12 ~ −19.75 | 0.331 | |
Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient.