Table 3.

Pre-S region mutations and deletions

	Clinical group	Genotype	Pre-S2 S tart codon	Deletions
				Region	Nucleotides		Amino acids		Region and functions affected
ID					Size	Position	Size	position
SDAC024	CR	D	ATG	Pre-S2	21	35-55a	7	16-22a
SDAC048	CR	D	ATG	Pre-S1	72	2998-3069	24	51-74	S promoter, Transactivator domain
SDAC083	CR	D	ATG	Pre-S2	21	35-55	7	16-22
SDAC097	CR	D	GTGb	Pre-S 2	9	45- 53	3	19-21
SDAC098	CH	D	ATG	Pre-S1	18	3129-3146	6	94-99	Hsc70 binding site, CCAAT binding factor (CBF) binding site, Cytosolic anchorage determinant (CAD)
SDAC112	ASC	D	ATG	Pre-S2	6	49-54	2	20-21
SDAC118	CR	D	ATG	Pre-S2	54	4-57	18	5 to 22	pHSA binding site, Viral secretion
SDAC107	CR	D	ATA	-	-	-	-	-	-
SDAC090	CR	D	ATA	-	-	-	-	-	-
SDAC058	CR	E	ATG	Pre-S2	9	58-66c	3	20-22c	Transactivator domain
SDAC059	HCC	E	GTG	Pre-S2	12	52-63	4	18-21	Transactivator domain
SDAC088	HCC	E	ATG	Pre-S2	12	52-63	4	18-21	Transactivator domain
SDAC095	HCC	E	ATG	Pre-S2	15	52-66	5	18-22	Transactivator domain
SDAC067	ASC	E	GTG	-	-	-	-	-	-
SDAC113	ASC	A	ACA	-	-	-	-	-	-

^a nucleotide or amino acid position relative to genotype D (GU456684).

^b mutant pre-S2 start codon italicized.

^c nucleotide or amino acid position relative to genotype E (AB205191).