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. 2013 May 25;13:258. doi: 10.1186/1471-2407-13-258

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Copyright © 2013 Yuan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lymphocyte infiltration at sites of focal capsule disruptions of normal appearing tissues. Paraffin-embedded human breast (A-B) and prostate (C-D) tissue sections were double immunostained for SMA (red) plus LCA (brown) or CK34βE12 plus LCA. Note that most infiltrating lymphocytes (arrows) are located on the site of focally disrupted epithelial capsules (circles), in which the overlying epithelial cells formed tongue-like projections invading the adjacent stroma. A and C: 100X. B and D: a higher (400X) magnification of A and C, respectively.