Figure 5.
Effect of AL on tumor growth arrest and angiogenesis inhibition in SW620-bearing mice. Daily oral treatment with AL at dosages of 20 mg/kg was initiated when tumor volumes reached approximately 120 mm3, as described in “Materials and methods.” A-C, AL resulted in tumor growth inhibition of 63% at day 27 as measured by tumor volume and weight with little toxicity at the tested dose. Same amount of pure refined corn oil served as vehicle controls. D, Immunohistochemical and TUNEL analysis showed that AL inhibited numbers of CD31-positive blood vessels and induced apoptosis in human colorectal cancer xenografts. Original magnification, ×400. **, P < 0.01 vs. control.