Figure 6. ERAP1-KO mice exhibit dramatically enhanced capabilities to respond to rEA and release pro-inflammatory cytokines.

C57BL/6 WT and ERAP1-KO mice were either mock (PBS) injected or intraperitoneally injected with 100 ng/mouse of rEA protein. n = 4 for all groups of mice. Plasma samples were collected at 6 hpi and were analyzed using a multiplexed bead array based quantitative system. Bars represent mean ± SEM. Statistical analysis was completed using two-tailed homoscedastic Student’s t-tests; *, ** - indicate values, statistically different between WT_rEA and ERAP1-KO_rEA groups, p<0.05, p<0.001, respectively.