Table 4. Overall and subgroup analyses of AGER gene T-374A polymorphism with the risk of developing CAD, and exploration of between-study heterogeneity and publication bias.
| Groups and subgroups | Studies (cases/controls), n (n/n) | Allele model | Dominant model | ||
| OR; 95% CI; P | I 2 (P χ2); P Egger | OR; 95% CI; P | I 2 (P χ2); P Egger | ||
| Total studies | 14 (2796/2209) | 0.97; 0.82–1.14; 0.713 | 61.7% (0.001); 0.567 | 0.97; 0.82–1.13; 0.658 | 31.7% (0.122); 0.876 |
| Total studies in DM | 7 (1058/1246) | 0.94; 0.74–1.21; 0.644 | 63.2% (0.012); 0.822 | 0.91; 0.72–1.17; 0.465 | 41.1% (0.117); 0.717 |
| Total studies in non-DM | 7 (1738/963) | 1.0; 0.78–1.27; 0.987 | 66.0% (0.007); 0.417 | 1.02; 0.82–1.26; 0.89 | 28.2% (0.213); 0.838 |
| Total studies in non-RD | 5 (886/899) | 0.87; 0.72–1.05; 0.137 | 11.3% (0.341); 0.57 | 0.91; 0.73–1.12; 0.363 | 0.0% (0.91); 0.577 |
| CAD endpoint | |||||
| CAD | 12 (1764/1634) | 0.98; 0.81–1.18; 0.801 | 55.2% (0.011); 0.71 | 0.96; 0.81–1.13; 0.595 | 15.3% (0.295); 0.972 |
| MI | 2 (1032/575) | 0.95; 0.58–1.54; 0.821 | 89.1% (0.002); 1.0 | 0.99; 0.58–1.69; 0.976 | 83.2% (0.015); 1.0 |
| Descent of populations | |||||
| Caucasian | 5 (1552/1069) | 0.89; 0.71–1.1; 0.279 | 67.1% (0.016); 0.817 | 0.95; 0.75–1.2; 0.662 | 46.2% (0.115); 0.516 |
| East Asian | 5 (976/926) | 0.98; 0.81–1.17; 0.806 | 0.0% (0.649); 0.627 | 0.99; 0.8–1.22; 0.893 | 0.0% (0.872); 0.86 |
| Middle Eastern | 3 (193/158) | 1.57; 1.09–2.24; 0.014 | 26.8% (0.255); 0.969 | 1.37; 0.88–2.13; 0.168 | 0.0% (0.659); 0.596 |
| African | 1 (75/56) | 0.48; 0.27–0.86; 0.013 | NA | 0.36; 0.18–0.74; 0.006 | NA |
| Study design | |||||
| Retrospective | 11 (2241/1511) | 0.97; 0.8–1.18; 0.751 | 64.3% (0.002); 0.198 | 0.93; 0.77–1.11; 0.425 | 31.3% (0.149); 0.573 |
| Prospective | 3 (555/698) | 0.99; 0.72–1.37; 0.956 | 50.9% (0.131); 0.176 | 1.12; 0.86–1.46; 0.408 | 11.1% (0.325); 0.095 |
| Age and/or gender | |||||
| Matched | 1 (691/234) | 0.74; 0.6–0.92; 0.005 | NA | 0.76; 0.55–1.03; 0.079 | NA |
| Unclear | 13 (2105/1975) | 1.01; 0.85–1.19; 0.697 | 56.1% (0.007); 0.805 | 1.0; 0.85–1.18; 0.991 | 25.6% (0.185); 0.493 |
| Total samples | |||||
| <300 subjects | 11 (1394/1264) | 0.97; 0.79–1.2; 0.808 | 59.0% (0.007); 0.579 | 0.96; 0.79–1.17; 0.659 | 23.0% (0.225); 0.992 |
| ≥300 subjects | 3 (1402/945) | 0.96; 0.71–1.31; 0.811 | 79.0% (0.008); 0.552 | 0.98; 0.72–1.33; 0.892 | 66.8% (0.049); 0.331 |
Abbreviations: DM, diabetes mellitus; RD, renal disease; CAD, coronary artery disease; MI, myocardial infarction; OR, odds ratio; 95% CI: 95% confidence interval; NA, not available.