Table 2. Univariate analyses of glucocorticoid (GC) dose and duration in relation to adrenal insufficiency at the first ACTH stimulation.

Treatment	Responders (n=76)	Non-responders (n=74)	Odds ratio (95% confidence interval)	P
GC dosage at M6 (mg/day)
<15	55	43
≥15	20	31	1.98 (1-3.9)	0.05
GC dosage at M12 (mg/day)
<9.5	66	46
≥9.5	10	28	4.0 (1.8-9.1)	0.0005
Time from diagnosis to the first ACTH test (months)
<19	60	43
≥19	16	31	2.7 (1.3-5.5)	0.006
Total amount of GCs received until the first ACTH test (mg)
<8500	63	41
≥8500	13	33	3.9 (1.8-8.3)	0.0003
Basal cortisol concentration (nmol/L)*
≥386	58	22
<386	18	52	7.62 (3.7-15.8)	<0.0001

M6 = after 6 months, M12 = after 12 months

* Multivariate analyses were adjusted to the basal cortisol concentration, if the total amount of GCs received until the first ACTH test was ≥8.5g, if the time from diagnosis to the first ACTH test was ≥19 months, GC dosage at M6 was ≥15 mg/d, GC dosage at M12 was ≥9.5 mg/day, gender, constitutional symptoms, fatigue, and pulsed methylprednisolone.