Table 2. Univariate analyses of glucocorticoid (GC) dose and duration in relation to adrenal insufficiency at the first ACTH stimulation.
Treatment | Responders (n=76) | Non-responders (n=74) | Odds ratio (95% confidence interval) | P |
---|---|---|---|---|
GC dosage at M6 (mg/day) | ||||
<15 | 55 | 43 | ||
≥15 | 20 | 31 | 1.98 (1-3.9) | 0.05 |
GC dosage at M12 (mg/day) | ||||
<9.5 | 66 | 46 | ||
≥9.5 | 10 | 28 | 4.0 (1.8-9.1) | 0.0005 |
Time from diagnosis to the first ACTH test (months) | ||||
<19 | 60 | 43 | ||
≥19 | 16 | 31 | 2.7 (1.3-5.5) | 0.006 |
Total amount of GCs received until the first ACTH test (mg) | ||||
<8500 | 63 | 41 | ||
≥8500 | 13 | 33 | 3.9 (1.8-8.3) | 0.0003 |
Basal cortisol concentration (nmol/L)* | ||||
≥386 | 58 | 22 | ||
<386 | 18 | 52 | 7.62 (3.7-15.8) | <0.0001 |
M6 = after 6 months, M12 = after 12 months
* Multivariate analyses were adjusted to the basal cortisol concentration, if the total amount of GCs received until the first ACTH test was ≥8.5g, if the time from diagnosis to the first ACTH test was ≥19 months, GC dosage at M6 was ≥15 mg/d, GC dosage at M12 was ≥9.5 mg/day, gender, constitutional symptoms, fatigue, and pulsed methylprednisolone.