Table 3. Selection of variables significantly associated with hospital mortality using logistic regression, within each of the four components of PIRO.

Variables	Total, n(%)	Non-survivors, n (%)	Regression coefficients	Adjusted OR	CI95%	p- value
Predisposition
Age
≤60 years	388 (38)	18 (5)		1.0
61–80 years	387 (37)	63 (16)	0.7	2.0	1.5–2.7	<0.001
>80 years	260 (25)	57 (22)	1.4	4.0	2.2–7.3	<0.001
Male sex, n (%)	506 (49)	79 (16)	0.6	1.8	1.2–2.6	0.005
Previous antibiotic therapy, n (%)	367 (36)	67 (18)	0.7	1.9	1.3–2.9	0.001
Chronic hepatic disease, n (%)	22 (2)	8 (36)	1.9	7.0	2.5–19.0	<0.001
Chronic haematologic disease, n (%)	60 (6)	17 (28)	1.5	4.3	2.2–8.5	<0.001
Cancer, n (%)	45 (4)	18 (40)	1.7	5.6	2.8–11.1	<0.001
Atherosclerosis, n (%)	242 (23)	54 (22)	0.5	1.6	1.0–2.4	0.050
Karnovsky index<70, n (%)	319 (31)	81 (25)	0.9	2.4	1.6–3.8	<0.001
Infection
Community-acquired, n (%)	493 (48)	47 (10)		1.0
Healthcare-associated, n (%)	225 (22)	32 (14)	0.5	1.6	1.0–2.5	0.064
Hospital-acquired, n (%)	316 (30)	59 (19)	0.8	2.2	1.4–3.3	<0.001
Response
Temperature
No alteration, n(%)	461 (45)	57 (12)		1.0
Fever, n (%)	336 (33)	35 (10)	−0.4	0.7	0.4–1.1
Hypothermia, n (%)	238 (22)	46 (19)	0.3	1.4	0.9–2.1
Tachypneia, n (%)	457 (44)	83 (18)	0.4	1.5	1.0–2.3	0.049
Hyperglycemia, n (%)	159 (15)	38 (24)	0.6	1.7	1.1–2.8	0.016
Severity of infection
Infection or sepsis, n (%)	645 (62)	50 (8)		1.0
Severe sepsis, n (%)	296 (29)	46 (15)	0.7	1.9	1.2–3.0	0.005
Septic shock, n (%)	94 (9)	42 (45)	2.0	7.4	4.4–12.6	<0.001
Organ dysfunction
Hypotension, n (%)	175 (17)	63 (36)	1.6	4.6	3.1–7.1	<0.001
SOFA>0	691 (67)	118 (17)	0.7	2.0	1.2–3.4	0.009

SOFA – Sepsis-related Organ Failure Assessment, OR – odds ratio, CI – confidence interval.