Figure 3. Graphical representation of the top network of differentially regulated genes (20 weeks).

Each network symbolizes the biological functions and/or diseases that were most significantly regulated 20 weeks after cardiac irradiation of Eng ^+/+ mice (n = 4–5) (A) and Eng ^+/− mice (n = 5) (B). The genes marked in red represent the upregulated genes and in green the downregulated genes. The solid arrows represent direct interactions and the dotted arrows indirect interactions. Genes circled in dark blue represents central molecules and the light blue lines direct interaction with other genes.