Table 2. Representation of differently regulated genes after 16 Gy irradiation using IPA approach.
| Eng+/+ 16 Gy | Eng+/− 16 Gy | Eng+/+ 16 Gy | Eng+/− 16 Gy | |
| Top upregulated genes | Top upregulated genes | Top downregulated genes | Top downregulated genes | |
| 4 weeks | SLN (6.2) | GDF15 (4.7) | C1orf51 (−3.0) | Hamp/Hamp2 (−4.9) |
| MYL7 (5.6) | Hsp70 (3.4) | PER2 (−2.3) | CA3 (−3.3) | |
| MYL4 (4.8) | MKI67 (3.2) | CA4 (−2.2) | TGFbRIII (−3.3) | |
| GDF15 (4.4) | PBK (3.1) | Hsp70 (−1.9) | Kcnip2 (−3.3) | |
| Hamp/Hamp2 (4.3) | IRF7 (3.1) | COQ10B (−1.8) | MYL7 (−3.2) | |
| 20 weeks | CA3 (4.8) | IGHA (3.7) | CHTOP (−2.1) | CDO1 (−3.5) |
| CFD (4.7) | GDF15 (3.5) | CXCL14 (−2.1) | Klra4 (−3.3) | |
| HP (3.4) | ESM1 (2.9) | Klra4 (−2.1) | Klk1b1 (−3.3) | |
| Hamp/Hamp2 (3.3) | HIST1H2AB (2.7) | ADH1C (−2.0) | INMT (−3.2) | |
| IRF7 (3.2) | PACSIN1 (2.6) | ALDOB (−1.9) | GUCY (−2.9) | |
| 40 weeks | ESM1 (3.9) | SLN (6.2) | Hsp70 (−4.3) | CCL21 (−5.0) |
| SRGN (3.5) | MYL7 (5.7) | CXCL14 (−3.3) | INMT (−4.3) | |
| HPRT1 (3.3) | CLASP1 (4.3) | ADH1C (−3.0) | Mup1 (−4.3) | |
| HOXB7 (3.2) | DKK3 (3.9) | TDRD3 (−2.8) | ADH1C (−4.2) | |
| C1orf52 (3.2) | SORBS1 (3.9) | CPXM1 (−2.8) | Ifitm1 (−3.7) |
The top 5 upregulated and downregulated genes per genotype are shown after 16 Gy at 4 weeks, 20 weeks and 40 weeks. Numbers in brackets show log2 ratio of sham treated mice versus 16 Gy irradiated mice.