Table 5. GO term enriched actin-related genes whose expression responds to the switch from polar to apolar growth in PglaA-racAG18V.
Predicted protein function* | Open reading frame code | Up/Down | Closest S. cerevisiae ortholog |
Rho GDP dissociation inhibitor | An18g04590 | ↑ | Rdi1 |
TORC2 and phosphoinositide PI4,5P(2) binding protein | An11g02840 | ↑ | Slm2 |
Arp2/3 complex subunit | An02g06360 | ↑ | Arc15 |
Arp2/3 complex subunit | An01g05510 | ↑ | Arc35 |
Arp2/3 complex subunit | An18g06590 | ↑ | Arc40 |
tropomyosin 1 | An13g00760 | ↑ | Tpm1 |
actin cortical patch component | An02g14620 | ↑ | Aip1 |
twinfilin | An04g09020 | ↑ | Twf1 |
actin-capping protein | An01g05290 | ↑ | Cap2 |
protein recruiting actin polymerization machinery | An10g00370 | ↑ | Bzz1 |
Genes up-regulated are indicated with ↑. Differential gene expression was evaluated by moderated t-statistics using the Limma package [82] with a FDR threshold at 0.05 [83]. Fold changes and statistical significance is given in Additional file 1 and 2.
: Protein functions were predicted based on information inferred from the Saccharomyces genome data base SGD (http://www.yeastgenome.org/) and the Aspergillus genome database AspGD (http://www.aspergillusgenome.org/).