Table 1. Overview of studies and nanomaterials.
Study | Exposure way | Particles | Deposited dose (µg) | Declared particle size | Agglomerated size in inhalation aerosol or instillation suspension | Reference |
1 | Intratracheal | NanoCB | 18, 54, 162 | 14 nm | 200 nm? | [20] |
instillation | NanoTiO2 | 18, 54, 162 | 17 nm | 100 nm? | ||
MWCNT | 18, 54, 162 | 40–50 nm×1–4 µm | ND§ | |||
SWCNT1 | 18, 54, 162 | 1.1 nm×0.5–100µm | ND§ | |||
SWCNT2 | 18, 54, 162 | 0.8–1.7nm×≤1 µm | ND§ | |||
2** | Intratracheal | MWCNT | 18, 54, 128 | 40–50 nm×1– 4 µm | ND§ | |
instillation | ||||||
3 | Inhalation | NanoCB | 75 | 14 nm | 65 nm‡ | [32] |
DEP | 19* | 1.62 µm† | 215 nm‡ | |||
4 | Inhalation | NanoTiO2 | 73 | 17 nm | 97 nm‡ | [19] |
5 | Inhalation | NanoCB | 287 | 14 nm | 310 nm (bimodal; 290 and 1500 nm)‡ | [22] |
6 | Intratracheal | Boiler dust | 216 | ND§ | ND§ | [31] |
instillation | Storage dust | 216 | ND§ | ND§ |
Based on a deposition fraction similar to NanoTiO2,† Mean diameter (number distribution) from National Institute of Standards and Technology, Certificate of Analysis, Standard Reference Material® 2975,‡ Geometric mean, § Not detetermined, ? Hydrodynamic size, ** Study 2 was an additional experiment performed to obtain plasma from MWCNT instilled mice and control animals.