Table 4. Relative Saa3 mRNA levels in lung and liver tissue after pulmonary deposition of particles by inhalation.
Particle | Study | Exposure set-up | Reference | 4–5 days after exposure | ∼4weeks after exposure | ||||||
Liver | Lung | Liver | Lung | ||||||||
Control | Exposed | Control | Exposed | Control | Exposed | Control | Exposed | ||||
NanoTiO2 | 4 | 11××1 h×42 mg/m3 | [23] | 201±336 | 70±51 | 24±12 | 570±418† | 605±369 | 486±283 | 1576±4329 | 3337±3808‡ |
(330±376)§ | (2384±1722)§ | ||||||||||
NanoCB | 5 | 11×1 h×42 mg/m3 | [22] | 52±27 | 116±48 | 15±8 | 43±16† | 44±33 | 79±47* | 15±6 | 43±16† |
Saa3 mRNA levels were normalised to 18S and multiplied by 107. Mean±SD is shown. * p<0.05, †p<0.01, ‡p<0.001, §One outlier has been removed in each group.