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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Biol Psychiatry. 2013 Apr 1;74(7):490–501. doi: 10.1016/j.biopsych.2013.02.021

Figure 3.

Figure 3

Hippocampal-induced facilitation of LFP response in the mPFC is not affected by cocaine exposure. (A) All recordings were conducted within the PD65-75 age period, which corresponds to 25–35 days from the last saline or cocaine injection (see Fig 2B). Ventral hippocampal train stimulation at 10Hz typically induces a sustained facilitation of LFP responses in the mPFC. Both saline and cocaine-treated animals exhibited similar pattern of prefrontal responses to the 10Hz-train stimulation (n=9 per group; main pulse number effect F(9,160)=2.27, *p<0.022; no significant treatment effect or treatment x pulse number interaction, two-way ANOVA). (B) Similarly, adult-treated rats exhibited similar degrees of LFP facilitation in response to hippocampal train stimulation at 10Hz (n=9 per group; main pulse number effect F(9,160)=2.29, *p=0.019; no significant treatment or treatment x pulse number effects, two-way ANOVA).