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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Neuroscience. 2013 May 21;247:376–385. doi: 10.1016/j.neuroscience.2013.05.018

Figure 5. Intrathecal injection of tPA elicits persistent mechanical allodynia.

Figure 5

(A) A single intrathecal injection of tPA (10 μg) induces rapid and persistent mechanical allodynia, as assessed by von Frey hairs. *P<0.05, vs. PBS control, t-test. n=4–7 mice. (B) Intrathecal injection of tPA (10 μg) does not produce heat hyperalgesia, as measured by radiant heat test (Hargreaves). P>0.05, vs. vehicle control, t-test, n=4–7 mice.