Figure 7. tPA-induced mechanical allodynia is attenuated by intrathecal inhibition of astrocytes and ERK.
(A, B) Partial reversal of intrathecal tPA (10 μg)-induced mechanical allodynia by intrathecal injection of the astrocyte toxin L-2-AA (A) and the MEK (ERK kinase) inhibitor U0126 (B). *P<0.05, vs. saline control, t-test. n=5 mice.