(A) Tyrosine hydroxylase immunoreactivity in putamen region in control subjects and patients with Parkinson’s disease with varying disease duration from time of diagnosis (n = 28). Representative tyrosine hydroxylase-stained post-commissural putamen sections from a control (A) and patients with Parkinson’s disease, with 1 year (B), 3 years (C), 4 years (D), 5 years (E), 11 years (F), 14 years (G), 15 years (H), 18 years (I), 19 years (J), 22 years (K) and 27 years (L) disease duration. Note the distinct intact tyrosine hydroxylase stained fibre band pattern in the medial putamen. Scale bar in L = 500 µm.