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Tyrosine hydroxylase immunoreactivity (TH-ir) decreases in SN region with the progression of disease. Representative nigra sections from a control (A) and patients with Parkinson’s disease, with a disease duration of 1 year (B), 4 years (C), 5 years (D), 7 years (E), 11 years (F), 14 years (G), 15 years (H), 18 years (I), 19 years (J), 22 years (K) and 27 years (L). Scale bar in L = 100 µm.
