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Platform to produce more complex IQAs. The “ad hoc IQA synthetic module” was prepared in S. cerevisiae to produce different IQAs from (S)-reticuline. Co-cultures of IQA producing E. coli and yeast cells efficiently produced (S)-reticuline and other IQAs. Further potential products are also shown with gene names. Broken lines indicate enzyme steps for which the genes have not yet been identified. The abbreviations used are as in Fig. 1.
