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. Author manuscript; available in PMC: 2013 Jul 25.
Published in final edited form as: Virology. 2011 Jan 31;412(1):196–210. doi: 10.1016/j.virol.2011.01.007

Figure 2. E4 sequence contains a conserved bipartite CDK consensus recognition motif.

Figure 2

(A) Homology between a bipartite CDK consensus recognition motif and E4 coding sequences of HPV types of the alpha genus. Six examples are given, but other types within the genus also contain the motif within the E4 ORF. They are: HPV61, 72, 81, 83 (species 3); HPV18, 39, 45, 59, 68 (species 7); HPV43 (species 8); HPV16, 31 (species 9); HPV6, 11, 13 (species 10); HPV54 (species 13). The potential CDK phosphorylation sites (S/TPX[K/R]) and cyclin binding motifs (RXL) in E4 are identified by a grey-shaded box. A threonine dipeptide in HPV16 E1^E4 that is a key determinant in cytoplasmic retention of CDK-cyclin complexes is underlined (Davy et al., 2005). (B) Details of a deletion and substitutions made within the bipartite CDK consensus recognition sequence of HPV18 E1^E4; the substitutions are underlined.