Figure 1. Anatomical distribution of intravenously injected ¹⁴C-AGE-BSA.

Mice from pre-pubertal, young-adult and old age groups were injected with ¹⁴C-AGE-BSA (4.7µg; 2×10⁶dpm), and killed at 1.5h, 24h, 1, 2, 3, 4, 5, or 8 weeks after injection for analyses of anatomical distribution of radioactivity. Results represent percentages of organ-associated radioactivity from total radioactivity recovered in listed organs at a given time point. Radioactivity in stomach, and small and large intestines were measured together with organ contents. * Value for empty urinary bladder, ** value for gallbladder with bile. Data represent mean values ± SD (n = 22 per organ). Since no significant difference in relative anatomical distribution of radioactivity was observed between either the age groups or the time points after ligand administration, pooled data were plotted in this figure.