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. 2013 Jul 23;4:93. doi: 10.3389/fphar.2013.00093

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Copyright © 2013 Pang, Du, Catchlove, Renoir, Lawrence and Hannan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Environmentally enriched alcohol abstinent mice do not display pro-depressive behaviors. (A) Schematic representation of experimental design leading up to behavioral testing. An identical design was used in the lead up to the DEX combinatorial challenges. (B) Reduced saccharin preference associated with alcohol abstinence was not observed in the enriched group. (C) Differences in saccharin preference test were not due to change in total fluid consumption. (D) Alcohol abstinent mice recorded significantly greater immobility times in the forced-swim test compared to water controls and enriched abstinent mice. Alc Abstn SH: 2 week alcohol abstinence in standard housing conditions; Alc Abstn EE: 2 week alcohol abstinence in environmentally enriched housing conditions. 10 mice per group. 1-way ANOVA followed by post-hoc Bonferroni's t-test: ^**p < 0.01; ^***p < 0.001.