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. 2013 Jul 23;4:93. doi: 10.3389/fphar.2013.00093

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Copyright © 2013 Pang, Du, Catchlove, Renoir, Lawrence and Hannan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Differential effects of enrichment on hypothalamic and pituitary gene expression. (A) Hypothalamic Crh expression was significantly reduced in the standard-housed Alc abstn group, and unaltered by enrichment. (B) Pituitary pomc1 expression was significantly reduced in the standard-housed Alc Abstn group but was significantly elevated in the enriched group. (C) Pituitary Drd2 expression was not significantly altered by alcohol abstinence. Alc Abstn SH: 2 week alcohol abstinence in standard housing conditions; Alc Abstn EE: 2 week alcohol abstinence in environmentally enriched housing conditions. 5–6 mice per group. 1-way ANOVA followed by post-hoc Bonferroni's t-test: ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.