Table 1.

Subcellular location changes of the final eight proteins between normal and cancer states

Protein	Tissue	Subcellular location changesa	Significance of P-values in t-testb
NSDHL	Kidney	(ER and Vesi.)→(Cytopl.)	ER(−): 4.75e-5
			Vesi.(−): 1.86e-7
			Cytopl.(+): 1.5e-12
	Urinary bladder	(ER and Vesi.)→(Cytopl.)	ER(−): 7.81e-7
			Vesi.(−): 3.02e-8
			Cytopl.(+): 8.6e-16
GOLGA5	Breast	(Gol.)→(ER)	Gol.(−): 5.42e-7
			ER(+): 0.0018
	Lung	(Gol.)→(ER)	Gol.(−): 5.26e-10
			ER(+): 2.77e-5
	Pancreas	(Gol.)→(ER)	Gol.(−): 2.90e-9
			ER(+): 4.60e-6
	Prostate	(Gol.)→(ER)	Gol.(−): 3.33e-10
			ER(+): 1.87e-6
	Thyroid gland	(Gol.)→(Mito.)	Gol.(−): 4.14e-6
			Mito.(+): 1.94e-6
	Urinary bladder	(Gol.)→(ER)	Gol.(−): 4.40e-7
			ER(+): 5.91e-4
HIP1	Lung	(Vesi.)→(Cytopl.)	Vesi.(−): 0.0039
			Cytopl.(+): 0.0067
ACTN4	Lung	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 0.0071
			Cytopl.(*): 0.3314
	Prostate	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 3.80e-4
			Cytopl.(*): 0.0457
	Kidney	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 0.0028
			Cytopl.(*): 0.0204
FHL2	Thyroid gland	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 0.0037
			Cytopl.(*): 0.7821
DBT	Pancreas	(Cytopl. and Mito.)→(Mito.)	Cytopl.(−): 9.60e-4
			Mito.(*): 0.0430
AHR	Breast	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 7.71e-6
			Cytopl.(*): 0.0375
	Pancreas	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 1.21e-4
			Cytopl.(*): 0.0049
	Prostate	(Cytopl. and Nucl.)→(Cytopl.)	Nucl.(−): 0.0056
			Cytopl.(*): 0.6544
CPT2c	lung	(Mito.)→(Cytopl. and Mito.)	Cytopl.(+): 0.0013
			Mito.(*): 0.1741

^a(Subcellular locations in normal tissue)→(Subcellular locations in cancer tissue).

^bThe P-values of involved translocations: ‘−’ means location missed in the cancerous tissue compared with the normal tissue, ‘+’ means new location in the cancerous tissue compared with the normal tissue, and ‘*’ means the same location in both normal and cancerous tissues.

^cThis biomarker is applicable to lung adenocarcinoma.