Fig. (1).

KATs and HDAC classes. Schematic depicting the balance of KAT and HDAC activities and the impact of this balance on chromatin conformation. The presence of acetyl groups (black balls) in the nucleosome histone tails relaxes the chromatin and facilitates the access of transcription factors. The boxes show the general classification of KAT and HDAC proteins and list representative examples for each group. For the KATs, we used the new nomenclature, but the former name or names are also indicated [30]. See the review articles [31, 156] for additional details.