Table 3.

An overview of endophenotypes assayed in rodent models of ASD.

Seizure susceptibility, sensory function, motor coordination, and anxiety-like behaviors are most commonly tested across models. Aggressive behavior, gastrointestinal function, and sleep cycles are generally understudied. Dual colored cells: formal aggression testing in Shank2^−/− mice did not yield data suggesting abnormal aggressive behavior, however excessive aggression was observed in home cages; PPA rats had impaired sensorimotor abilities when tested using the beam task but showed no change in swim speed in other assays. VPA, rodents administered valproate.