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Major molecular cascades regulating LTD. AMPAR, AMPA receptor; mGluR1, metabotropic glutamate receptor 1; Gq, Gq protein; PLC, phospholipase C; DG, diacylglycerol; PKC, protein kinase C; IP3, inositol 1,4,5-trisphosphate; IP3R, IP3 receptor; VGCC, voltage-gated Ca2+ channel; ER, endoplasmic reticulum.
