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(a) Muscle biopsy of the heterozygous carrier sister, (II-2) at age 35 years with centrally located small type 1 fiber filled with black-stained LDs. (b) Interfilamentous and subsarcolemmar lipid deposition on EM. (c) Neutral LDs (arrows) in granulocytes of the heterozygous sister (III-3) at age 4 years. ((a) Sudan Black B, (b and c) EM, bar=1 μm).
