Table 2. Comparison of interesting regions of linkage meta-analysis with the personality GWAS meta-analysis.

Trait	Bin	Cyto	SRP-value	ORP-value	PHET	Approx. region (mbp)	SNP GWAS (N>17 000)	β	Effect allele	MAF	Effective no. of SNPs in the regiona	P-value (nominal)	Bonferroni thresholdb	Candidate gene	Distance of the SNP to the candidate gene (kb)c
Extraversion	9.6	9q34	0.003	0.049	0.036	125–150	rs11103814	−0.35	A	0.33	2049	1.3 × 1−05	4.2 × 1−06	OLFM1, KIAA0649	204.8, 153.8
	10.4	10q24	0.017	0.042	0.063	75–100	rs7922066	−0.44	A	0.18	2986	4.2 × 1−06	2.1 × 1−06	CRTAC1	Intron(NM_001206528.1)
	10.5	10q24	0.018	0.015	0.042	100–125	rs7905091	0.47	T	0.13	3073	2.5 × 1−05	2.1 × 1−06	LOXL4, PYROXD2	18.1, 97.2
	11.5	11q22	0.005	0.024	0.073	100–125	rs12419614	1.65	A	0.03	3177	1.1 × 1−04	2.0 × 1−06	GRIA4	Intron(NM_000829.3)
Openness	2.1	2p25	0.067	0.016	0.186	0–25	rs11685318	−0.38	A	0.20	3056	1.0 × 1−05	1.8 × 1−06	PDIA6, KCNF1	40.4, 58.7
	9.1	9p21	0.045	0.011	0.053	0–25	rs10966354	−0.30	T	0.37	3865	3.1 × 1−05	1.4 × 1−06	ELAVL2, TUSC1	810.7, 1039.6
	11.6	11q24	0.034	0.043	0.625	125–150	rs677035	−0.56	T	0.08	1393	2.6 × 1−06	4.4 × 1−06	FLI1, KCNJ1	13.9, 10.9
	15.4	15q26	0.045	0.031	0.280	75–100	rs8034376	−0.47	T	0.11	3135	2.0 × 1−04	2.0 × 1−06	FAM169B, IGF1R	6.5, 128.6
	19.3	19q13	0.048	0.007	0.165	50–75	rs2287826	−0.62	A	0.07	2106	1.2 × 1−04	4.8 × 1−06	LILRA4, LAIR1	12.8, 1.9
Agreeableness	4.8	4q34	0.003	0.048	0.008	175–200	rs13113475	0.28	A	0.20	1959	4.8 × 1−05	3.1 × 1−06	SPCS3, VEGFC	228.8, 122.5
	19.1	19p13	0.011	0.042	0.134	0–25	rs10413538	0.49	T	0.28	3209	3.7 × 1−04	3.6 × 1−06	ZNF826	Utr-5(NM_001039884.1)

P-values from GWAS significant after Bonferroni correction in bold italics.

^aEffective number of SNPs from the GWAS present in the bin.

^bBonferroni threshold based on the total number of SNPs (both genotyped and imputed) from the GWAS present in the bin.

^cPositions are taken from dbSNP (http://www.ncbi.nlm.nih.gov/snp) and SCAN (http://www.scandb.org/newinterface/about.html) databases.