Table 4.
Virological response and change of serum HBV DNA level after treatment.
| Treatment response | Treatment group (n = 200) | Control group (n = 100) | χ 2/t | P values |
|---|---|---|---|---|
| 24 weeks | ||||
| Patients with HBV DNA level decline >2 log10 IU/mL, n (%) | 14 (7.00) | 3 (3.00) | 1.9954 | 0.1578※ |
| Patients with undetectable HBV, n (%) | 1 (0.5) | 0 (0) | 0.0000 | 1.0000※★ |
| Reduction in HBV DNA level, mean (SD), log10 IU/mL | ||||
| Total | 0.34 (0.92) | 0.06 (0.62) | 3.2094 | 0.0015△ |
| baseline level 5 to <7 log10 IU/mL | 0.48 (0.98) | 0.05 (0.39) | 1.9532 | 0.0584△ |
| baseline level 7 to <9 log10 IU/mL | 0.26 (0.96) | 0.06 (0.67) | 1.7470 | 0.0822△ |
| baseline level >9 log10 IU/mL | 0.63 (0.58) | 0.05 (0.46) | 3.3742 | 0.0016# |
| 52 weeks | ||||
| Patients with HBV DNA level decline >2 log10 IU/mL, n (%) | 38 (19.00) | 5 (5.00) | 10.6416 | 0.0011※ |
| Patients with undetectable HBV a, n (%) | 1 (0.5) | 1 (1.00) | 0.0000 | 1.0000※★ |
| Reduction in HBV DNA level, mean (SD), log10 IU/mL | ||||
| Total | 0.86 (1.27) | 0.05 (0.86) | 6.4772 | 0.0000△ |
| baseline level 5 to <7 log10 IU/mL | 1.10 (0.79) | 0.05 (0.47) | 4.0849 | 0.0002# |
| baseline level 7 to <9 log10 IU/mL | 0.76 (1.38) | 0.05 (0.47) | 4.4885 | 0.0000△ |
| baseline level >9 log10 IU/mL | 1.05 (1.06) | 0.06 (0.68) | 3.8132 | 0.0005△ |
SD: standard deviation; HBV: hepatitis B virus.
aHBV DNA < 12 IU/mL.
※Chi-square test.
# t-test.
△Adjusted t-test.
★Continuity correction.