Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Compounds 5a-e were synthesized as shown. 2-Nitroso-6-benzyloxy-9-Boc-purine (3) was synthesized from 6-benzyloxypurine (1) in 4 steps using published procedures.15,16 Compound 3 was then condensed with the appropriate aniline in dichloromethane in the presence of acetic acid at room temperature to give the corresponding 4a-e.17 Deprotection of the 9-t-Boc group was carried out using an equivalent amount of piperidine in dichloromethane to give the target azo prodrug 5a-e.16
