TABLE 1.

Phenotype and History of Sickle Cell Disease Morbidity in the 21 Children

Patient	Age	Gender	Sickle cell phenotype	ACS episodes in past 2 years	Pain episodes in past 2 years	History of ICU admission
Patients with a positive challenge
1	5.1	F	SS	1	0	Yes1
2	10.5	M	Sβthal+1	1	3	No
3	8.0	F	SS	2	4	No
4	15.1	F	SS	0	2	Yes2
53	8.5	M	SS	NA3	NA3	Yes1,2
6	7.8	M	SS	0	0	Yes1,2
7	9.2	M	SS	0	1	No
8	18.7	M	SS	2	5	Yes2
9	12.3	M	SS	3	4	No
10	8.6	F	Sβthal0	2	4	No
11	14.0	M	SS	0	1	No
12	15.9	F	SS	0	6	Yes2
13	13.1	F	SS	0	8	Yes
14	17.1	F	SS	1	4	Yes1
Patients with a negative challenge
15	13.5	M	SC	2	5	No
16	8.0	M	SS	0	1	Yes1
17	9.7	F	SS	0	1	Yes1
184	8.8	F	SS	04	0	No
19	13.4	F	SS	0	3	No
20	14.7	F	SS	0	1	No
21	7.6	M	SS	4	5	Yes1,2

¹Patients with a history intubation during ICU admission.

²Patients with a history of exchange transfusion during ICU admission.

³This patient was referred from another center for evaluation that included the methacholine challenge and no hospital records were available.

⁴Only patient with no history of an ACS episode.