Table 2.
Girls | Group 1 (Tanner stage 1) (n = 7) | Group 2 (Tanner stages 2–3) (n = 14) | Group 3 (Tanner stages 4–5) (n = 20) | P value |
---|---|---|---|---|
Age (yrs) | 10·4 ± 0·7*,† | 12·2 ± 1·2*,‡ | 14·9 ± 1·3†,‡ | <0·0001 |
BMI-SDS | −0·13 ± 0·81 | −0·22 ± 0·61 | 0·28 ± 0·81 | NS |
GH baseline (ng/ml)§ | 1·55 ± 2·05 | 1·72 ± 2·48 | 1·88 ± 3·50 | NS |
GH nadir (ng/ml)§ | 0·10 ± 0·05† | 0·37 ± 0·31‡ | 0·19 ± 0·15 | 0·02 |
GH AUC (ng/ml) | 82·5 ± 86·5 | 235·9 ± 235·0 | 114·9 ± 135·2 | 0·09 |
IGF-1 (ng/ml) | 155·3 ± 67·2* | 229·5 ± 132·0 | 312·8 ± 92·0‡ | 0·008 |
P1NP (ng/ml)¶ | 381·9 ± 178·8 (216·6–547·3) | 692·5 ± 364·0* (472·5–912·5) | 239·9 ± 211·6† (239·9–211·6) | 0·0009 |
CTX (ng/ml)¶ | 1·1 ± 0·6† (0·42–1·77) | 2·4 ± 1·3*,‡ (1·37–3·37) | 1·1 ± 0·6† (0·77–1·47) | 0·006 |
25(OH) vitamin D (ng/ml) | 34·6 ± 6·8 | 33·9 ± 15·9 | 26·9 ± 9·3 | NS |
Means ± SDS.
P < 0·05 compared with Group 3.
P < 0·05 compared with Group 2.
P < 0·05 compared with Group 1.
Comparisons performed with log-transformed values to approximate a normal distribution.
Ranges provided for aminoterminal propeptide of type 1 procollagen (P1NP) and carboxy-terminal collagen crosslinks (CTX) indicate the 5th and 95th confidence intervals.