Table 1.

Associations between HLA class I and leprosy.

Population	Study design	Sample size	Phenotype	Serotype, allele, or haplotype	Type of association	P or Pc	Ref.
Ethiopian	Case-control	20TT, 19LL, 36 controls	TT	Aw21	Susceptibility	Pc = 0.042	[7]
Indian	Case-control	30BT or TT, 40 controls	TT	A9	Resistance	Pc = 0.005	[8]
Thai	Case-control	26TT, 183 controls	TT	A2 Bw17	Resistance Susceptibility	0.01 < P < 0.05   0.01 < P < 0.05	[9]
	Case-control	70LL, 183 controls	LL	B7	Susceptibility	0.01 < P < 0.05
Iran	Case-control	88LD, 125 controls	LL	A1 B35	Resistance Susceptibility	P < 0.05	[10]
Mumbai/Indian	Case-control	158LL, 150TT, 170 controls	LL LL LL TT/LL TT/LL	B-40 Aw19 A2-B40 A11-B40 A24-B40	Susceptibility Resistance Susceptibility Susceptibility Susceptibility	Pc = 0.0027   Pc = 0.02   P < 0.00025   P < 0.00025   P < 0.00025	[11]
Japanese	Case-control	295LL, 74TL, 110 controls	LL	B7 Bw54	Susceptibility Resistance	Pc = 0.044   Pc = 0.016	[12]
Korean	Case-control	157LD, 162 controls	LD	A2 A11 Aw33 Cw5	Resistance Susceptibility Susceptibility Resistance	P = 0.03   P = 0.03   P = 0.003   P = 0.001	[13]
Indian	Case-control	65ENL, 71LL	ENL	A11	Susceptibility	Pc = 0.0035	[14]
Indian	Case-control	68LL, 237 controls	LL	B60	Susceptibility	Pc = 0.00019
	Case-control	138LD, 237 controls	LD	B60	Susceptibility	Pc = 0.031	[15]
	Case-control	20BB, 237 controls	BB	B40	Susceptibility	Pc = 0.018
Southern Chinese	Case-control	50LL, 69 controls	LL	B46	Resistance	P < 0.01	[16]
Turkish	Case-control	80LD, 120 controls	LD	A9 A10 Bw4 Bw6 Cw1 Cw2 A3 B49	Susceptibility Susceptibility Susceptibility Susceptibility Susceptibility Susceptibility Resistance Resistance	Pc = 0.0004   Pc = 0.0226   Pc = 0.00003   Pc = 0.00001   Pc = 0.0080   Pc = 0.0055   Pc = 0.0040   Pc = 0.0035	[17]
Southern Indian	Case-control	32LD, 67 controls	LD	A*02:06   A*11:02   B*51 : 10   B*18:01   C*04:07   C*07:03   C*04:11	Susceptibility Susceptibility Susceptibility Susceptibility Susceptibility Susceptibility Resistance	Pc = 0.000007   Pc = 0.00001   Pc = 0.0000005   Pc = 0.007   Pc = 1.0 × 10−9   Pc = 0.000001   Pc = 0.001	[18]
Mumbai/Indian	Case-control	103LD, 101 controls	LD	A02 A11 A28 B12 B15 B40 Cw7 Cw3	Susceptibility Susceptibility Resistance Resistance Resistance Susceptibility Susceptibility Resistance	Pc = 0.0015   Pc = 0.009   Pc = 0.0014   Pc = 0.001   Pc = 0.05   Pc = 7.34 × 10−7   Pc = 2.26 × 10−5   Pc = 0.0002	[19]
	Case-control	32ML, 67 controls	ML	A*02:06   A*11:02   B*18:01   B*51:10   C*04:07   C*04:11   C*07:03	Susceptibility Susceptibility Susceptibility Susceptibility Susceptibility Resistance Susceptibility	Pc = 7.15 × 10−5   Pc = 0.00001   Pc = 0.007   Pc = 5.29 × 10−6   Pc = 5.12 × 10−9   Pc = 0.001   Pc = 1.97 × 10−5
	Case-control	32ML, 67 controls	ML	A*11-B*40	Susceptibility	Pc = 0.002
Brazilian	Case-control	224LD, 446 controls	LD	A*11   B*38   C*12   C*16	Susceptibility Susceptibility Susceptibility Resistance	P = 0.0345   P = 0.0402   P = 0.01   P = 0.0124	[20]
	Case-control	88LL, 48TT	LL	C*07   B*35   C*04	Susceptibility Resistance Resistance	P = 0.0211   P = 0.0156   P = 0.0464
Vietnamese	family study	198 families	LD	C*15:05	Susceptibility	P = 0.0063
	family study	292 families	LD	C*15:05	Susceptibility	P = 8.8 × 10−5	[21]
Indian	Case-control	364LD, 371 controls	LD	C*15:05	Susceptibility	P = 3.0 × 10−8

MB: multibacillary leprosy; LL: lepromatous leprosy; BB: borderline borderline; TT: tuberculoid leprosy; ENL: erythema nodosum leprosum; LD: leprosy disease; ns: not significant; Pc: corrected P Value; Ref.: reference.