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. 2013 Jul 8;2013:989837. doi: 10.1155/2013/989837

Table 1.

Associations between HLA class I and leprosy.

Population Study design Sample size Phenotype Serotype, allele, or haplotype Type of association P or Pc Ref.
Ethiopian Case-control 20TT, 19LL, 36 controls TT Aw21 Susceptibility Pc = 0.042 [7]
Indian Case-control 30BT or TT, 40 controls TT A9 Resistance Pc = 0.005 [8]
Thai Case-control 26TT, 183 controls TT A2
Bw17		 Resistance
Susceptibility		 0.01 < P < 0.05  
0.01 < P < 0.05		 [9]
Case-control 70LL, 183 controls LL B7 Susceptibility 0.01 < P < 0.05
Iran Case-control 88LD, 125 controls LL A1
B35		 Resistance
Susceptibility		 P < 0.05 [10]
Mumbai/Indian Case-control 158LL, 150TT, 170 controls LL
LL
LL
TT/LL
TT/LL		 B-40
Aw19
A2-B40
A11-B40
A24-B40		 Susceptibility
Resistance
Susceptibility
Susceptibility
Susceptibility		 Pc = 0.0027  
Pc = 0.02  
P < 0.00025  
P < 0.00025  
P < 0.00025		 [11]
Japanese Case-control 295LL, 74TL, 110 controls LL B7
Bw54		 Susceptibility
Resistance		 Pc = 0.044  
Pc = 0.016		 [12]
Korean Case-control 157LD, 162 controls LD A2
A11
Aw33
Cw5		 Resistance
Susceptibility
Susceptibility
Resistance		 P = 0.03  
P = 0.03  
P = 0.003  
P = 0.001		 [13]
Indian Case-control 65ENL, 71LL ENL A11 Susceptibility Pc = 0.0035 [14]
Indian Case-control 68LL, 237 controls LL B60 Susceptibility Pc = 0.00019  
Case-control 138LD, 237 controls LD B60 Susceptibility Pc = 0.031 [15]
Case-control 20BB, 237 controls BB B40 Susceptibility Pc = 0.018  
Southern Chinese Case-control 50LL, 69 controls LL B46 Resistance P < 0.01 [16]
Turkish Case-control 80LD, 120 controls LD A9
A10
Bw4
Bw6
Cw1
Cw2
A3
B49 		Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance
Resistance		 Pc = 0.0004  
Pc = 0.0226  
Pc = 0.00003  
Pc = 0.00001  
Pc = 0.0080  
Pc = 0.0055  
Pc = 0.0040  
Pc = 0.0035		 [17]
Southern Indian Case-control 32LD, 67 controls LD A*02:06  
A*11:02  
B*51 : 10  
B*18:01  
C*04:07  
C*07:03  
C*04:11 		Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance		 Pc = 0.000007  
Pc = 0.00001  
Pc = 0.0000005  
Pc = 0.007  
Pc = 1.0 × 10−9  
Pc = 0.000001  
Pc = 0.001		 [18]
Mumbai/Indian Case-control 103LD, 101 controls LD A02
A11
A28
B12
B15
B40
Cw7
Cw3		 Susceptibility
Susceptibility
Resistance
Resistance
Resistance
Susceptibility
Susceptibility
Resistance		 Pc = 0.0015  
Pc = 0.009  
Pc = 0.0014  
Pc = 0.001  
Pc = 0.05  
Pc = 7.34 × 10−7  
Pc = 2.26 × 10−5  
Pc = 0.0002		 [19]
Case-control 32ML, 67 controls ML A*02:06  
A*11:02  
B*18:01  
B*51:10  
C*04:07  
C*04:11  
C*07:03 		Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance
Susceptibility		 Pc = 7.15 × 10−5  
Pc = 0.00001  
Pc = 0.007  
Pc = 5.29 × 10−6  
Pc = 5.12 × 10−9  
Pc = 0.001  
Pc = 1.97 × 10−5
Case-control 32ML, 67 controls ML A*11-B*40 Susceptibility Pc = 0.002
Brazilian Case-control 224LD, 446 controls LD A*11  
B*38  
C*12  
C*16 		Susceptibility
Susceptibility
Susceptibility
Resistance		 P = 0.0345  
P = 0.0402  
P = 0.01  
P = 0.0124		 [20]
Case-control 88LL, 48TT LL C*07  
B*35  
C*04 		Susceptibility
Resistance
Resistance		 P = 0.0211  
P = 0.0156  
P = 0.0464
Vietnamese family study 198 families LD C*15:05 Susceptibility P = 0.0063  
family study 292 families LD C*15:05 Susceptibility P = 8.8 × 10−5 [21]
Indian Case-control 364LD, 371 controls LD C*15:05 Susceptibility P = 3.0 × 10−8  

MB: multibacillary leprosy; LL: lepromatous leprosy; BB: borderline borderline; TT: tuberculoid leprosy; ENL: erythema nodosum leprosum; LD: leprosy disease; ns: not significant; Pc: corrected P Value; Ref.: reference.